随着计算能力的兴起，使用数据驱动的方法来共同设计机器人的形态和控制器已成为一种可行的方法。然而，评估每个形态下控制器的适应性是耗时的。作为开创性数据驱动的方法，共同适应利用了双NETWORK机制，目的是学习以形态学参数为条件的Q功能，以取代对各种候选者的传统评估，从而加快优化的速度。在本文中，我们发现共同适应在参数传输期间训练和状态行动分布变化期间的勘探误差的存在，这损害了性能。我们提出了在线和离线RL方法的并发网络的框架。通过灵活地利用行为克隆术语，我们可以减轻上述问题对结果的影响。进行仿真和物理实验以证明我们所提出的方法优于基线算法，这说明了所提出的方法是发现形态和控制器的最佳组合的有效方法。

近年来，基于对比的自我监督学习方法取得了巨大的成功。但是，自学要求非常长的训练时期（例如，MoCO V3的800个时代）才能获得有希望的结果，这对于一般学术界来说是不可接受的，并阻碍了该主题的发展。这项工作重新审视了基于动量的对比学习框架，并确定了两种增强观点仅产生一个积极对的效率低下。我们提出了快速MOCO-一个新颖的框架，该框架利用组合贴片从两个增强视图中构造了多对正面，该视图提供了丰富的监督信号，这些信号带来了可忽视的额外计算成本，从而带来了显着的加速。经过100个时期训练的快速MOCO实现了73.5％的线性评估精度，类似于经过800个时期训练的MOCO V3（Resnet-50骨干）。额外的训练（200个时期）进一步将结果提高到75.1％，这与最先进的方法相当。几个下游任务的实验也证实了快速MOCO的有效性。

我们研究通过应用具有多个初始化的梯度上升方法来源的估计器的统计特性。我们派生了该估算器的目标的人口数量，并研究了从渐近正常性和自举方法构成的置信区间（CIS）的性质。特别是，我们通过有限数量的随机初始化来分析覆盖范围。我们还通过反转可能性比率测试，得分测试和WALD测试来调查CI，我们表明所得到的CIS可能非常不同。即使MLE是棘手的，我们也提出了一种两个样本测试程序。此外，我们在随机初始化下分析了EM算法的性能，并通过有限数量的初始化导出了CI的覆盖范围。

Weakly-supervised object localization aims to indicate the category as well as the scope of an object in an image given only the image-level labels. Most of the existing works are based on Class Activation Mapping (CAM) and endeavor to enlarge the discriminative area inside the activation map to perceive the whole object, yet ignore the co-occurrence confounder of the object and context (e.g., fish and water), which makes the model inspection hard to distinguish object boundaries. Besides, the use of CAM also brings a dilemma problem that the classification and localization always suffer from a performance gap and can not reach their highest accuracy simultaneously. In this paper, we propose a casual knowledge distillation method, dubbed KD-CI-CAM, to address these two under-explored issues in one go. More specifically, we tackle the co-occurrence context confounder problem via causal intervention (CI), which explores the causalities among image features, contexts, and categories to eliminate the biased object-context entanglement in the class activation maps. Based on the de-biased object feature, we additionally propose a multi-teacher causal distillation framework to balance the absorption of classification knowledge and localization knowledge during model training. Extensive experiments on several benchmarks demonstrate the effectiveness of KD-CI-CAM in learning clear object boundaries from confounding contexts and addressing the dilemma problem between classification and localization performance.

Late-life depression (LLD) is a highly prevalent mood disorder occurring in older adults and is frequently accompanied by cognitive impairment (CI). Studies have shown that LLD may increase the risk of Alzheimer's disease (AD). However, the heterogeneity of presentation of geriatric depression suggests that multiple biological mechanisms may underlie it. Current biological research on LLD progression incorporates machine learning that combines neuroimaging data with clinical observations. There are few studies on incident cognitive diagnostic outcomes in LLD based on structural MRI (sMRI). In this paper, we describe the development of a hybrid representation learning (HRL) framework for predicting cognitive diagnosis over 5 years based on T1-weighted sMRI data. Specifically, we first extract prediction-oriented MRI features via a deep neural network, and then integrate them with handcrafted MRI features via a Transformer encoder for cognitive diagnosis prediction. Two tasks are investigated in this work, including (1) identifying cognitively normal subjects with LLD and never-depressed older healthy subjects, and (2) identifying LLD subjects who developed CI (or even AD) and those who stayed cognitively normal over five years. To the best of our knowledge, this is among the first attempts to study the complex heterogeneous progression of LLD based on task-oriented and handcrafted MRI features. We validate the proposed HRL on 294 subjects with T1-weighted MRIs from two clinically harmonized studies. Experimental results suggest that the HRL outperforms several classical machine learning and state-of-the-art deep learning methods in LLD identification and prediction tasks.

Learning 3D human pose prior is essential to human-centered AI. Here, we present GFPose, a versatile framework to model plausible 3D human poses for various applications. At the core of GFPose is a time-dependent score network, which estimates the gradient on each body joint and progressively denoises the perturbed 3D human pose to match a given task specification. During the denoising process, GFPose implicitly incorporates pose priors in gradients and unifies various discriminative and generative tasks in an elegant framework. Despite the simplicity, GFPose demonstrates great potential in several downstream tasks. Our experiments empirically show that 1) as a multi-hypothesis pose estimator, GFPose outperforms existing SOTAs by 20% on Human3.6M dataset. 2) as a single-hypothesis pose estimator, GFPose achieves comparable results to deterministic SOTAs, even with a vanilla backbone. 3) GFPose is able to produce diverse and realistic samples in pose denoising, completion and generation tasks. Project page https://sites.google.com/view/gfpose/

Bayesian networks (BNs) are a widely used graphical model in machine learning for representing knowledge with uncertainty. The mainstream BN structure learning methods require performing a large number of conditional independence (CI) tests. The learning process is very time-consuming, especially for high-dimensional problems, which hinders the adoption of BNs to more applications. Existing works attempt to accelerate the learning process with parallelism, but face issues including load unbalancing, costly atomic operations and dominant parallel overhead. In this paper, we propose a fast solution named Fast-BNS on multi-core CPUs to enhance the efficiency of the BN structure learning. Fast-BNS is powered by a series of efficiency optimizations including (i) designing a dynamic work pool to monitor the processing of edges and to better schedule the workloads among threads, (ii) grouping the CI tests of the edges with the same endpoints to reduce the number of unnecessary CI tests, (iii) using a cache-friendly data storage to improve the memory efficiency, and (iv) generating the conditioning sets on-the-fly to avoid extra memory consumption. A comprehensive experimental study shows that the sequential version of Fast-BNS is up to 50 times faster than its counterpart, and the parallel version of Fast-BNS achieves 4.8 to 24.5 times speedup over the state-of-the-art multi-threaded solution. Moreover, Fast-BNS has a good scalability to the network size as well as sample size. Fast-BNS source code is freely available at https://github.com/jjiantong/FastBN.

Using a Bayesian network to analyze the causal relationship between nodes is a hot spot. The existing network learning algorithms are mainly constraint-based and score-based network generation methods. The constraint-based method is mainly the application of conditional independence (CI) tests, but the inaccuracy of CI tests in the case of high dimensionality and small samples has always been a problem for the constraint-based method. The score-based method uses the scoring function and search strategy to find the optimal candidate network structure, but the search space increases too much with the increase of the number of nodes, and the learning efficiency is very low. This paper presents a new hybrid algorithm, MCME (multiple compound memory erasing). This method retains the advantages of the first two methods, solves the shortcomings of the above CI tests, and makes innovations in the scoring function in the direction discrimination stage. A large number of experiments show that MCME has better or similar performance than some existing algorithms.

Consider a finite sample from an unknown distribution over a countable alphabet. Unobserved events are alphabet symbols which do not appear in the sample. Estimating the probabilities of unobserved events is a basic problem in statistics and related fields, which was extensively studied in the context of point estimation. In this work we introduce a novel interval estimation scheme for unobserved events. Our proposed framework applies selective inference, as we construct confidence intervals (CIs) for the desired set of parameters. Interestingly, we show that obtained CIs are dimension-free, as they do not grow with the alphabet size. Further, we show that these CIs are (almost) tight, in the sense that they cannot be further improved without violating the prescribed coverage rate. We demonstrate the performance of our proposed scheme in synthetic and real-world experiments, showing a significant improvement over the alternatives. Finally, we apply our proposed scheme to large alphabet modeling. We introduce a novel simultaneous CI scheme for large alphabet distributions which outperforms currently known methods while maintaining the prescribed coverage rate.

Despite high global prevalence of hepatic steatosis, no automated diagnostics demonstrated generalizability in detecting steatosis on multiple international datasets. Traditionally, hepatic steatosis detection relies on clinicians selecting the region of interest (ROI) on computed tomography (CT) to measure liver attenuation. ROI selection demands time and expertise, and therefore is not routinely performed in populations. To automate the process, we validated an existing artificial intelligence (AI) system for 3D liver segmentation and used it to purpose a novel method: AI-ROI, which could automatically select the ROI for attenuation measurements. AI segmentation and AI-ROI method were evaluated on 1,014 non-contrast enhanced chest CT images from eight international datasets: LIDC-IDRI, NSCLC-Lung1, RIDER, VESSEL12, RICORD-1A, RICORD-1B, COVID-19-Italy, and COVID-19-China. AI segmentation achieved a mean dice coefficient of 0.957. Attenuations measured by AI-ROI showed no significant differences (p = 0.545) and a reduction of 71% time compared to expert measurements. The area under the curve (AUC) of the steatosis classification of AI-ROI is 0.921 (95% CI: 0.883 - 0.959). If performed as a routine screening method, our AI protocol could potentially allow early non-invasive, non-pharmacological preventative interventions for hepatic steatosis. 1,014 expert-annotated liver segmentations of patients with hepatic steatosis annotations can be downloaded here: https://drive.google.com/drive/folders/1-g_zJeAaZXYXGqL1OeF6pUjr6KB0igJX.